Drew Cain’s time in General Hospital has always been marked by turmoil, betrayal, and relentless scheming. For over a decade, this character, played by Cameron Mathison, has been at the heart of some of Port Charles’ darkest and most twisted storylines. Now, after 11 long years, Drew’s journey is coming to an explosive and heartbreaking conclusion.

From the destruction he sowed in Michael and Willow’s marriage to the manipulation of Portia, Curtis, and their daughter Trina, Drew’s list of enemies grows longer by the day. His actions have left deep scars on the lives of those around him, pushing friendships, families, and alliances to the brink.

Among the most pivotal players are the Corinthos family—Sonny, Michael, and Carly—each harboring justified resentment. Drew’s manipulation and deceit have made him a prime target for retribution, especially as the police investigation circles ever closer to Sonny, raising tensions throughout the city.

Trina, bearing the weight of Drew’s blackmail and his ruinous interference in her life and Kai’s football career, emerges as a deeply conflicted character. Emotionally stretched to her limits, Trina’s involvement adds a volatile edge to the growing mystery. Could she be the one to finally stop Drew’s reign of terror?

But Trina is far from the only suspect. Nina’s fury over Drew’s duplicity and affair with both her and Willow adds another layer of danger. With Ava’s support and family ties running deep, Nina’s simmering anger threatens to boil over into drastic action.

Meanwhile, Curtis and Portia find themselves locked in their own storm. Curtis grapples with protecting his family from Drew’s blackmail, while Portia wrestles with guilt and the need to reclaim her power. Both face decisions that could push them beyond their limits.

As the whodunnit unfurls, the community watches, breathless, as secrets unravel and suspicions mount. General Hospital’s writers are poised to deliver one of the most gripping murder mysteries in the show’s history, weaving together emotional payoffs and shocking twists.

Drew’s exit promises not just the end of a villain, but a catharsis for Port Charles itself. The fallout will determine who survives the storm, who falls, and who will bear the weight of Drew’s legacy for years to come.

So, who will snap first? Will Trina take justice into her own hands, or is a darker, more calculating player hiding in the shadows? The questions linger as fans eagerly await the explosive resolution.

What’s your theory? Who do you think will be responsible for Drew’s shocking downfall? Share your thoughts below!