The first major loss is Monica Quartermaine. With the real-life passing of her actress earlier this year, writers are reportedly crafting a beautiful, heartbreaking sendoff. Monica’s death will mark the end of an era—a matriarch who connected decades of storylines. Her memorial service is expected to draw old and new faces, complete with tributes, flashbacks, and even video messages from distant characters. But in true Quartermaine fashion, Monica’s will may ignite a bitter feud over inheritance, with Tracy Quartermaine at the center of the chaos. Allegations of favoritism, secret assets, and surprise heirs could dominate the aftermath.

Equally gut-wrenching is the rumored passing of Leslie Webber. Laura Collins’ mother, and one of the show’s legacy characters, will reportedly die off-screen. Her funeral, however, will be anything but peaceful. Hints suggest a mysterious Cassadine relative will appear, using the gathering to stir up old vendettas and raise new questions about the family’s history. For Laura, it’s a personal and political loss—one that could shake her role as Port Charles’ moral compass.

Meanwhile, chaos unfolds within Nina Reeves’ world. In a bold move, Curtis Ashford exposed Nina’s secret affair with Drew Cain just moments before Willow’s wedding. His confession, meant to protect his own family, shattered Nina’s already fragile bond with her daughter. The fallout was immediate and brutal. Willow severed all ties. Nina was left alone, reeling from both betrayal and heartbreak.

Curtis later attempted to apologize, explaining his motivations were rooted in desperation. In an emotionally raw scene at Nina’s Crimson office, he confessed everything. But the damage had already been done. Willow’s trust is gone, and Nina is now confronting a life-altering truth: her past mistakes may have destroyed her future relationship with her only child.

Compounding the heartbreak, rumors swirl about the shocking death of Jack Brennan. Once a divisive figure, Brennan had evolved into a promising romantic interest for Carly. Their chemistry was undeniable, their connection refreshing. His potential death—possibly tied to a dangerous WSB mission—threatens to push Carly back into Sonny’s orbit, a pairing many fans feel has long run its course.

While the fifth death remains a mystery, speculation points toward characters like Jen Sidwell or Marco Rios—names tied to the underworld and mob intrigues. Others fear it could be Drew Kane, whose manipulations have made him a rising villain. Regardless, the ripple effects of these deaths will be seismic.

As secrets unravel and legacies crumble, General Hospital reminds us why it remains at the top of daytime drama. In Port Charles, love, revenge, and redemption are never far apart. But the question remains—who will survive the storm ahead?